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COLORECTAL CANCER

Gastric metaplasia could initiate the serrated neoplasia pathway in CRC

Nature Reviews Gastroenterology & Hepatology volume 19, pages 217–218 (2022)Cite this article

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A subset of colorectal cancers arises from sessile serrated lesions. Tumorigenesis via the serrated neoplasia pathway is largely unexplored. Now, a new study suggests that this pathway is initiated by gastric metaplasia induced by damage and repair, which is triggered by disadvantageous composition of microbiota in the proximal colon.

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Fig. 1: Gastric metaplasia caused by microbial dysbiosis might initiate the serrated neoplasia pathway in colorectal cancer.

References

  1. Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021).

    PubMed  Google Scholar 

  2. IJspeert, J. E. G., Medema, J. P. & Dekker, E. Colorectal neoplasia pathways: state of the art. Gastrointest. Endosc. Clin. N. Am. 25, 169–182 (2015).

    Article  Google Scholar 

  3. Chen, B. et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 184, 6262–6280 (2021).

    Article  CAS  Google Scholar 

  4. Xiao, Y. & Freeman, G. J. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 5, 16–18 (2015).

    Article  CAS  Google Scholar 

  5. IJspeert, J. E. G. et al. Prevalence, distribution and risk of sessile serrated adenomas/polyps at a center with a high adenoma detection rate and experienced pathologists. Endoscopy 48, 740–746 (2016).

    Article  Google Scholar 

  6. Ahuja, N. et al. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res. 58, 5489–5494 (1998).

    CAS  PubMed  Google Scholar 

  7. Dejea, C. M. et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc. Natl Acad. Sci. USA 111, 18321–18326 (2014).

    Article  CAS  Google Scholar 

  8. Muller, C. et al. Risk of colorectal cancer in serrated polyposis syndrome: a systematic review and meta-analysis. Clin.Gastroenterol. Hepatol. 20, 622–630 (2022).

    Article  CAS  Google Scholar 

  9. Ensari, A. et al. Serrated polyps of the colon: how reproducible is their classification? Virchows Arch. 461, 495–504 (2012).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands

    Joep E. G. IJspeert & Evelien Dekker

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  1. Joep E. G. IJspeert
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  2. Evelien Dekker
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Correspondence to Evelien Dekker.

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Competing interests

E.D. received a research grant from FujiFilm, honorarium for consultancy from FujiFilm, Olympus, GI Supply, CPP-FAP, PAION and Ambu, and speakers’ fees from Olympus, GI Supply, Norgine, IPSEN, PAION and FujiFilm. J.E.G.I. declares no competing interests.

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IJspeert, J.E.G., Dekker, E. Gastric metaplasia could initiate the serrated neoplasia pathway in CRC. Nat Rev Gastroenterol Hepatol 19, 217–218 (2022). https://doi.org/10.1038/s41575-022-00592-z

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