Chromosomal abnormalities in multiple myeloma

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Multiple myeloma (MM) is a malignancy of plasma cells that manifests clinically as hypercalcaemia, renal impairment, anaemia and/or bone disease. MM is preceded by the precursor syndromes monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM).

Primary genetic alterations that underlie MGUS, SMM and MM are chromosomal translocations that involve IGH (encoding immunoglobulin heavy-chains) and hyperdiploidy. Further genetic aberrations, such as copy number alterations, complex structural events and other mutations are involved in disease progression and, in some cases, are associated with treatment resistance.

This poster from Nature Reviews Disease Primers illustrates the process of plasma cell development and summarizes the genetic alterations that are associated with development and progression of MM. This poster also highlights the frequencies of these genetic alterations.

This poster is freely available online thanks to support from STEMCELL Technologies.

The poster has been peer reviewed and, as always, Springer Nature retains sole responsibility for all editorial content.

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Authors and Affiliations

1. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK

   Aneta Mikulasova

2. NYU Langone Medical Center, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA

   Gareth J. Morgan

3. Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology Oncology, Indiana University, Indianapolis, IN, USA

   Brian A. Walker

Authors

1. Aneta Mikulasova
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2. Gareth J. Morgan
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3. Brian A. Walker
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Correspondence to Aneta Mikulasova, Gareth J. Morgan or Brian A. Walker.

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Mikulasova, A., Morgan, G.J. & Walker, B.A. Chromosomal abnormalities in multiple myeloma. Nat Rev Dis Primers 8, 42 (2022). https://doi.org/10.1038/s41572-022-00374-6

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• Published: 16 June 2022

• DOI: https://doi.org/10.1038/s41572-022-00374-6