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Colorectal cancer

TNT and local recurrence in the RAPIDO trial — untangling the puzzle

Nature Reviews Clinical Oncology volume 20, pages 357–358 (2023)Cite this article

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Neoadjuvant chemotherapy offers a pragmatic alternative to the difficulties associated with delivering timely adjuvant chemotherapy in rectal cancer. Enthusiasm for administering neoadjuvant therapy to all patients with locally advanced rectal cancer is based on data from several phase III trials. Data from the RAPIDO trial are a critical component of this evidence.

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Fig. 1: Fragmentation of locally advanced rectal cancers following an extended delay between radiotherapy and surgery.

References

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Authors and Affiliations

  1. Radiotherapy Department, Mount Vernon Centre for Cancer Treatment, Northwood, UK

    Robert Glynne-Jones

  2. Department of Colorectal Surgery, West Hertfordshire Teaching Hospitals NHS Trust, Watford, UK

    James Hollingshead

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  1. Robert Glynne-Jones
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  2. James Hollingshead
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Correspondence to Robert Glynne-Jones.

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Competing interests

R.G.-J. has acted as an advisor and/or consultant of Amgen and Incyte and has received honoraria for lectures from Servier and Johnson & Johnson. J.H. declares no competing interests.

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Glynne-Jones, R., Hollingshead, J. TNT and local recurrence in the RAPIDO trial — untangling the puzzle. Nat Rev Clin Oncol 20, 357–358 (2023). https://doi.org/10.1038/s41571-023-00751-4

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