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Boosting mitochondrial metabolism with dietary supplements in heart failure

Nature Reviews Cardiology volume 18, pages 685–686 (2021)Cite this article

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Dietary supplementation with NAD+ precursors or ketone esters has been shown to improve mitochondrial function in preclinical models of heart failure with either reduced or preserved ejection fraction. Both supplementation approaches hold promise but are in the early stages of development as clinical therapies for heart failure.

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Fig. 1: Potential mechanisms of dietary supplements to boost mitochondrial metabolism in HF.

References

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Acknowledgements

The authors receive grant support from the NIH: R01 HL126209 and HL144937 to K.D.O. and R.T.; and HL110349, HL142628 and HL149695 to R.T.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA

    Kevin D. O’Brien & Rong Tian

  2. Mitochondrial and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA

    Rong Tian

Authors
  1. Kevin D. O’Brien
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  2. Rong Tian
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Correspondence to Kevin D. O’Brien or Rong Tian.

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Competing interests

K.D.O. and R.T. are listed as co-inventors on a patent application submitted by the University of Washington, USA, regarding targeting NAD+ metabolism to treat inflammation in heart failure. R.T. is a member of the Scientific Advisory Board of Cytokinetics, USA.

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O’Brien, K.D., Tian, R. Boosting mitochondrial metabolism with dietary supplements in heart failure. Nat Rev Cardiol 18, 685–686 (2021). https://doi.org/10.1038/s41569-021-00610-8

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