Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Viral pathogenesis

SARS and synapses

Nature Microbiology (2024)Cite this article

Subjects

SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle interference with normal synaptic transmission.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A role for SARS-CoV-2 and synaptic transmission.

References

  1. Partiot, E. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01657-2 (2024).

    Article  PubMed  Google Scholar 

  2. Taquet, M. et al. Nat. Med. 29, 2498–2508 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Paul, J., Strickland, S. & Melchor, J. P. J. Exp. Med. 204, 1999–2008 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Stein, S. R. et al. Nature 612, 758–763 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mavrikaki, M., Lee, J. D., Solomon, I. H. & Slack, F. J. Nat. Aging 2, 1130–1137 (2022).

    Article  PubMed  Google Scholar 

  6. Yang, A. C. et al. Nature 595, 565–571 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Greene, C. et al. Nat. Neurosci. 27, 421–432 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Etter, M. M. et al. Nat. Commun. 13, 6777 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Meinhardt, J. et al. Nat. Rev. Neurosci. 25, 30–42 (2024).

    Article  CAS  PubMed  Google Scholar 

  10. Song, E. et al. J. Exp. Med. 218, e20202135 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Neurotherapeutics Discovery, Department of Neurology, Pediatrics, Neuroscience, Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA

    Harris A. Gelbard

  2. Department of Chemistry, University of Rochester, Rochester, NY, USA

    Wesley Chiang

  3. Center for Neurotherapeutics Discovery, University of Rochester Medical Center, Rochester, NY, USA

    Wesley Chiang

Authors
  1. Harris A. Gelbard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wesley Chiang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Harris A. Gelbard.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gelbard, H.A., Chiang, W. SARS and synapses. Nat Microbiol (2024). https://doi.org/10.1038/s41564-024-01685-y

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41564-024-01685-y

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing