Analyses refuting the dogma that a quarter of the world’s population is latently infected with Mycobacterium tuberculosis emphasize the need for a redirection of research priorities.
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References
Behr, M. A., Edelstein, P. H. & Ramakrishnan, L. Br. Med. J. 362, k2738 (2018).
Global Tuberculosis Report 2021 (WHO, 2021); https://go.nature.com/3re4n6j
Wellcome and the Gates Foundation to Fund Late-Stage Development of a Tuberculosis M72 Vaccine Candidate That Could Be the First in 100 Years if Proven Effective (Bill & Melinda Gates Foundation, 2023); https://go.nature.com/3VVlv8L
Nat. Microbiol. 8, 1601–1602 (2023).
Tozer, L. Nature https://doi.org/10.1038/d41586-023-02171-x (2023).
Behr, M. A., Edelstein, P. H. & Ramakrishnan, L. Br. Med. J. 367, l5770 (2019).
Emery, J. C. et al. Proc. R. Soc. B 288, 20201635 (2021).
Global Tuberculosis Report 2023 (WHO, 2023); https://go.nature.com/3PW21Nk
Divangahi, M., Khan, N. & Kaufmann, E. Front. Immunol. 9, 2976 (2018).
Roy Chowdhury, R. et al. Nature 560, 644–648 (2018).
Acknowledgements
M.A.B. is supported by a Tier 1 Canada Research Chair from the Canadian Institutes for Health Research. L.R. is supported by a Principal Research Fellowship from the Wellcome Trust and a Research Project Grant (RO1) from the National Institutes of Health.
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Nature Microbiology thanks Brian Robertson and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Behr, M.A., Edelstein, P.H. & Ramakrishnan, L. Rethinking the burden of latent tuberculosis to reprioritize research. Nat Microbiol (2024). https://doi.org/10.1038/s41564-024-01683-0
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DOI: https://doi.org/10.1038/s41564-024-01683-0