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CANCER MICROENVIRONMENT

Netrin-4 regulates stiffness and metastasis

Nature Materials volume 20, pages 722–723 (2021)Cite this article

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The stiffness of the basement membrane is a determinant of the process of metastasis and patient survival. Netrin-4 is now shown to be a key regulator of the basement membrane stiffness.

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Fig. 1: Netrin-4 inhibits metastatic dissemination via BM softening.

References

  1. Chang, J. & Chaudhuri, O. J. Cell Biol. 218, 2456–2469 (2019).

    Article  Google Scholar 

  2. Weaver, A. M. Clin. Exp. Metastasis 23, 97–105 (2006).

    Article  Google Scholar 

  3. Cáceres, R. et al. Proc. Natl Acad. Sci. USA 115, 11537–11542 (2018).

    Article  Google Scholar 

  4. Nam, S. & Chaudhuri, O. Nat. Phys. 14, 621–628 (2018).

    Article  CAS  Google Scholar 

  5. Cheung, K. J., Gabrielson, E., Werb, Z. & Ewald, A. J. Cell 155, 1639–1651 (2013).

    Article  CAS  Google Scholar 

  6. Glentis, A. et al. Nat. Commun. 8, 924 (2017).

    Article  Google Scholar 

  7. Sirka, O. K., Shamir, E. R. & Ewald, A. J. J. Cell. Biol. 217, 3368–3381 (2018).

    Article  CAS  Google Scholar 

  8. Reuten, R. et al. Nat. Mater. https://doi.org/10.1038/s41563-020-00894-0 (2021).

  9. van de Vijver, M. J. et al. N. Engl. J. Med. 347, 1999–2009 (2002).

    Article  Google Scholar 

  10. Reuten, R. et al. Nat. Commun. 7, 13515 (2016).

    Article  CAS  Google Scholar 

  11. Wei, S. C. et al. Nat. Cell Biol. 17, 678–688 (2015).

    Article  CAS  Google Scholar 

  12. Fattet, L. et al. Dev. Cell 54, 302–316 (2020).

    Article  CAS  Google Scholar 

  13. Zhang, K. et al. Nat. Cell Biol. 15, 677–687 (2013).

    Article  CAS  Google Scholar 

  14. Paget, S. Lancet 1, 571–573 (1889).

    Article  Google Scholar 

Download references

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  1. Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Université Claude Bernard Lyon 1, Centre Léon Bérard, Lyon, France

    Patrick Mehlen & Laurent Fattet

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  1. Patrick Mehlen
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  2. Laurent Fattet
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Correspondence to Patrick Mehlen.

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The authors declare no competing interests.

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Mehlen, P., Fattet, L. Netrin-4 regulates stiffness and metastasis. Nat. Mater. 20, 722–723 (2021). https://doi.org/10.1038/s41563-021-01012-4

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