New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Cholesterol-modified sphingomyelin chimeric lipid bilayer for improved therapeutic delivery
Nature Communications Open Access 07 March 2024
-
CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma
Journal of Translational Medicine Open Access 10 October 2023
-
Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
Military Medical Research Open Access 28 April 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gerlowski, L. E. & Jain, R. K. Microvasc. Res. 31, 288–305 (1986).
Matsumura, Y. & Maeda, H. Cancer Res. 46, 6387–6392 (1986).
Hobbs, S. K. et al. Proc. Natl Acad. Sci. USA 95, 4607–4612 (1998).
Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016).
Anselmo, A. C. & Mitragotri, S. Bioeng. Transl. Med. 4, e10143 (2019).
Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017).
Petersen, G. H., Alzghari, S. K., Chee, W., Sankari, S. S. & La-Beck, N. M. J. Control Release. 232, 255–264 (2016).
Nel, A., Ruoslahti, E. & Meng, H. ACS Nano. 11, 9567–9569 (2017).
Sindhwani, S. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0566-2 (2019).
McNeil, S. E. Nat. Rev. Mater. 1, 16073 (2016).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Lázaro, I., Mooney, D.J. A nanoparticle’s pathway into tumours. Nat. Mater. 19, 486–487 (2020). https://doi.org/10.1038/s41563-020-0669-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41563-020-0669-9
This article is cited by
-
Cholesterol-modified sphingomyelin chimeric lipid bilayer for improved therapeutic delivery
Nature Communications (2024)
-
Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
Military Medical Research (2023)
-
CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma
Journal of Translational Medicine (2023)
-
Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion
Nano Research (2023)
-
Functional Peptides from One-bead One-compound High-throughput Screening Technique
Chemical Research in Chinese Universities (2023)