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COACERVATES

Multiphase model membraneless organelles

Nature Chemistry volume 14, pages 1095–1097 (2022)Cite this article

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Quantitatively studying the partitioning of biomolecules and reaction equilibria in cellular systems is an enormous challenge. Now, a multiphase coacervate model system provides insight into this complex biological problem, illustrating how coexisting phases influence RNA partitioning and duplex dissociation.

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Fig. 1: RNA partitioning and dissociation equilibrium in multiphase coacervate models for membraneless organelles.

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Authors and Affiliations

  1. Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China

    Shuqi Wu & Liangfei Tian

  2. Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Liangfei Tian

  3. Innovation Center for Smart Medical Technologies & Devices, Binjiang Institute of Zhejiang University, Hangzhou, China

    Liangfei Tian

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  1. Shuqi Wu
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  2. Liangfei Tian
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Correspondence to Liangfei Tian.

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Wu, S., Tian, L. Multiphase model membraneless organelles. Nat. Chem. 14, 1095–1097 (2022). https://doi.org/10.1038/s41557-022-01043-7

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