The compact state of chromatin induced by the methylation of lysine 9 on histone H3 has long been implicated in a heritable state of transcriptional repression. A study now shows that transient deposition of H3K9me3 helps to stabilize stalled DNA replication forks, while its reversal enables accurate fork restart.
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Gasser, S.M. Transient chromatin compaction in fork restart. Nat Cell Biol 25, 931–932 (2023). https://doi.org/10.1038/s41556-023-01181-1
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DOI: https://doi.org/10.1038/s41556-023-01181-1