The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV functions. This Comment discusses the roles and biogenesis of the EV corona, as well as the importance of controls to determine whether a biological effect is attributable to the internal EV cargo or to the corona associated with the EV exofacial surface.
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References
Théry, C. et al. J. Extracell. Vesicles 7, 1535750 (2018).
Tóth, E. Á. et al. J. Extracell. Vesicles 10, e12140 (2021).
Palviainen, M. et al. PLoS One 15, e0236439 (2020).
Yerneni, S. S., Solomon, T., Smith, J. & Campbell, P. G. Biochim. Biophys. Acta Gen. Subj. 1866, 130069 (2022).
Wolf, M. et al. J. Extracell. Vesicles 11, e12207 (2022).
Sung, B. H. et al. Nat. Commun. 6, 7164 (2015).
Varga, Z. et al. Colloids Surf. B Biointerfaces 192, 111053 (2020).
Santucci, L. et al. Sci. Rep. 9, 13048 (2019).
Buzás, E. I., Tóth, E. Á., Sódar, B. W. & Szabó-Taylor, K. É. Semin. Immunopathol. 40, 453–464 (2018).
Meneghetti, M. C. et al. J. R. Soc. Interface. 12, 0589 (2015).
Toledo, A. G. et al. J. Histochem. Cytochem. 69, 105–119 (2021).
Baglio, S. R. et al. Clin. Cancer Res. 23, 3721–3733 (2017).
Genschmer, K. R. et al. Cell 176, 113–126.e15 (2019).
Németh, A. et al. Sci. Rep. 7, 8202 (2017).
Lázaro-Ibáñez, E. et al. J. Extracell. Vesicles 8, 1656993 (2019).
Michell, D. L. & Vickers, K. C. Biochim. Biophys Acta 1861, 2069–2074 (2016).
van Niel, G. et al. Cell Rep. 13, 43–51 (2015).
Solvik, T. A. et al. J. Cell Biol. 221, e202110151 (2022).
Welton, J. L. et al. J. Extracell. Vesicles 6, 1369805 (2017).
Papini, E., Tavano, R. & Mancin, F. Front. Immunol. 11, 567365 (2020).
Willis, C. M. et al. Proc. Natl Acad. Sci. USA 116, 10488–10493 (2019).
Busatto, S. et al. J. Nanobiotechnology 18, 162 (2020).
Luga, V. et al. Cell 151, 1542–1556 (2012).
Ugalde, C. L. et al. J. Extracell. Vesicles 10, e12034 (2020).
Wu, J. Y. et al. J. Nanobiotechnology 19, 405 (2021).
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The author is a member of the advisory board of Sphere Gene Therapeutics Inc. (Boston, USA).
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Buzas, E.I. Opportunities and challenges in studying the extracellular vesicle corona. Nat Cell Biol 24, 1322–1325 (2022). https://doi.org/10.1038/s41556-022-00983-z
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DOI: https://doi.org/10.1038/s41556-022-00983-z