The Rag GTPases form the link between extracellular nutrients and the activation of mTORC1. RagA/B and RagC/D have been considered functionally redundant, but two studies now show that each isoform and gene have specific features, making their control of mTORC1 activity more nuanced and complex than previously appreciated.
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References
Sancak, Y. et al. Science 320, 1496–1501 (2008).
Shen, K. et al. Nature 556, 64–69 (2018).
Petit, C. S., Roczniak-Ferguson, A. & Ferguson, S. M. J. Cell Biol. 202, 1107–1122 (2013).
Li, K. et al. PLoS Biol. 20, e3001594 (2022).
Demetriades, C., Doumpas, N. & Teleman, A. A. Cell 156, 786–799 (2014).
Figlia, G. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00977-x (2022).
Gollwitzer, P., Grutzmacher, N., Wilhelm, S., Kummel, D. & Demetriades, C. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00976-y (2022).
Napolitano, G. et al. Nature 585, 597–602 (2020).
Gosis, B. S. et al. Science 376, eabf8271 (2022).
Alesi, N. et al. Nat. Commun. 12, 4245 (2021).
Di Malta, C. et al. Science 356, 1188–1192 (2017).
Yang, S. et al. Dev. Cell 55, 272–288.e5 (2020).
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Alesi, N., Henske, E.P. Keeping up with the Rag GTPases. Nat Cell Biol 24, 1330–1331 (2022). https://doi.org/10.1038/s41556-022-00981-1
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DOI: https://doi.org/10.1038/s41556-022-00981-1
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