Intrinsically disordered regions are a ubiquitous class of protein domains that lack a fixed 3D structure. Here, an evolutionarily conserved family of disordered CO2 sensors has been discovered, expanding the growing repertoire of disordered regions that respond to changes in the cellular environment.
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A.S.H. is a scientific consultant with Dewpoint Therapeutics. R.J.E. has no competing interests.
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Emenecker, R.J., Holehouse, A.S. Intrinsically disordered CO2 sensors. Nat Cell Biol 24, 1013–1014 (2022). https://doi.org/10.1038/s41556-022-00957-1
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DOI: https://doi.org/10.1038/s41556-022-00957-1