The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE complex and explains the importance of forces generated by actin filaments to control new actin generation at the leading edge.
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Petrie, R. J. & Yamada, K. M. J. Cell. Sci. 125, 5917–5926 (2012).
Mehidi, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00786-8 (2021).
Papalazarou, V. & Machesky, L. M. Curr. Opin. Cell Biol. 68, 37–44 (2021).
Ura, S. et al. Curr. Biol. 22, 553–561 (2012).
Weiner, O. D. et al. PLoS Biol. 4, e38 (2006).
Millius, A., Watanabe, N. & Weiner, O. D. J Cell Sci. 125, 1165–1176 (2012).
Gohl, C. et al. J. Biol. Chem. 285, 40171–40179 (2010).
Singh, S. P. et al. PLoS Biol. 18, e3000774 (2020).
Andrew, N. & Insall, R. H. Nat Cell Biol. 9, 193–200 (2007).
Pipathsouk, A. et al. J. Cell Biol. 220, e202003086 (2021).
Fort, L. et al. Nat Cell Biol. 20, 1159–1171 (2018).
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Machesky, L.M., Insall, R.H. WAVE complex regulation by force. Nat Cell Biol 23, 1111–1112 (2021). https://doi.org/10.1038/s41556-021-00790-y
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DOI: https://doi.org/10.1038/s41556-021-00790-y