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CELL THERAPIES

Universally non-immunogenic iPSCs

Inactivation of the major histocompatibility complex and overexpression of the transmembrane protein CD47 renders induced pluripotent stem cells invisible to the immune system of the host.

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Fig. 1: Engineered hypoimmunogenic iPSCs via MHC class-I/II knockout and CD47 overexpression.

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Correspondence to Jacob H. Hanna.

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Shani, T., Hanna, J.H. Universally non-immunogenic iPSCs. Nat Biomed Eng 3, 337–338 (2019). https://doi.org/10.1038/s41551-019-0401-8

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