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GRP20 regulates micro-exon retention via interaction with the spliceosome during flower development

Splicing is important for regulation of gene expression programmes, including those involved in plant development or plant environmental responses. In our study, we report that GRP20 regulates Arabidopsis gene expression by ensuring the proper splicing of thousands of floral and leaf RNAs, including the retention of micro exons in conserved floral homeotic genes. GRP20 binds to RNAs and interacts with the spliceosome, and both events are required for normal splicing and flower development.

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Fig. 1: Abnormal floral organ number in the grp20 mutants and micro exon retention regulated by GRP20.

References

  1. Deng, X. & Cao, X. F. Roles of pre-mRNA splicing and polyadenylation in plant development. Curr. Opin. Plant Biol. 35, 45–53 (2017). A Review article about RNA splicing regulation in plant development.

    Article  CAS  PubMed  Google Scholar 

  2. Lee, Y. & Rio, D. C. Mechanisms and regulation of alternative pre-mRNA splicing. Annu. Rev. Biochem. 84, 291–323 (2015). A Review article that presents the mechanisms and regulators that ensure accuracy of RNA splicing.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ustianenko, D., Weyn-Vanhentenryck, S. M. & Zhang, C. L. Micro exons: discovery, regulation, and function. WIREs RNA 8, 1418 (2017). A Review article that presents the discovery of micro exons and the functions of genes containing micro exons.

    Article  Google Scholar 

  4. Atambayeva, S. A., Khailenko, V. A. & Ivashchenko, A. T. Intron and exon length variation in Arabidopsis, rice, nematode, and human. Mol. Biol. 42, 312–320 (2008). This article reports the distribution of intron and exon length in representative plants and animals.

    Article  CAS  Google Scholar 

  5. Irish, V. The ABC model of floral development. Curr. Biol. 27, 887–890 (2017). A Review article that presents the ABC model of floral organ identity and its conservation among angiosperms.

    Article  Google Scholar 

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This is a summary of: Wang, J. et al. Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development. Nat. Plants https://doi.org/10.1038/s41477-023-01605-8 (2024).

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GRP20 regulates micro-exon retention via interaction with the spliceosome during flower development. Nat. Plants 10, 11–12 (2024). https://doi.org/10.1038/s41477-023-01606-7

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