The Lycopodium alkaloids represent a valuable source of neuroactive compounds. The biosynthesis of these specialized metabolites is now shown to involve three α-carbonic anhydrase-like enzymes that are responsible for constructing the key carbon–carbon bonds within their distinctive polycyclic alkaloid structures.
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Ushimaru, R., Abe, I. Assembling neuroactive alkaloids. Nat. Plants 9, 1946–1947 (2023). https://doi.org/10.1038/s41477-023-01586-8
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DOI: https://doi.org/10.1038/s41477-023-01586-8