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A contemporary assessment of the evaluation and management of patients presenting to a tertiary medical center with Peyronie’s disease

International Journal of Impotence Research volume 36, pages 118–124 (2024)Cite this article

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Abstract

Peyronie’s disease continues to be poorly understood. We characterize the presenting features of Peyronie’s disease within a large cohort and elucidate the factors that correlate with surgical intervention. Univariate and multivariate analyses were performed on 1483 consecutive patients to assess pre-operative predictors of surgical intervention for Peyronie’s disease. Overall, 1263 patients met inclusion criteria. Mean age was 55.4 ± 11.1 years with a mean duration of disease at presentation of 33.2 ± 42.5 months. Mean primary curvature was 49.8 ± 20.8°. Primary ventral curvature was present in 11.4% and 36.5% of patient had a multiplanar curvature. During penile duplex ultrasound evaluation indentation/narrowing deformities were appreciated in 76.0%, hourglass deformity in 10.1%, and hinge effect in 33.0% of patients. Calcification was seen in 30.1% of patients. Operative intervention occurred in 35.3% of patients. Degree of primary curvature (1.03 OR, p < 0.001), hourglass deformity (1.82 OR, p = 0.01), decreased tunical elasticity (1.20 OR, p = 0.03), and prior intralesional collagenase clostridium histolyticum injections (2.94 OR, p < 0.001) predicted surgical correction on multivariate analysis. Compared to historical studies, we found a higher incidence of severe degree of curvature (27.5% >60°), indentation deformities, hinge-effect, multiplanar curvature and penile calcifications. Ultimately, predictors of surgical intervention included those with worse erectile function and more severe characteristics.

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Additional data are available from the corresponding author on request.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Rush University Medical Center Department of Urology, 1725 West Harrison Street, Chicago, IL, 60612, USA

    Daniel Roadman & Laurence Levine

  2. The Urology Group, 2000 Joseph E Sanker Blvd, Cincinnati, OH, 45212, USA

    Vinson Wang

  3. Buffalo General Medical Center, 100 High Street Buffalo, Buffalo, NY, 14203, USA

    Adam Beer

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  1. Daniel Roadman
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  2. Vinson Wang
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  3. Adam Beer
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  4. Laurence Levine
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Contributions

Study conceptualization was performed by DR, VW, and LL. Methodology, formal data collection, and investigation were performed by DR, VW, AB. Formal data analysis was performed by DR, VW, AB, and LL. Writing of original manuscript draft was performed by DR and AB. Review and editing of subsequent drafts were performed by VW and LL.

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Correspondence to Laurence Levine.

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Roadman, D., Wang, V., Beer, A. et al. A contemporary assessment of the evaluation and management of patients presenting to a tertiary medical center with Peyronie’s disease. Int J Impot Res 36, 118–124 (2024). https://doi.org/10.1038/s41443-023-00738-w

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