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The 100 most-cited publications on Peyronie’s disease: a bibliometric analysis and visualization study

Abstract

This study aimed to summarize the characteristics of the top 100 most-cited publications on Peyronie’s disease (PD) research and to analyse past and current research hotspots and trends. The SCI-E database of the Web of Science Core Collection (WoSCC) provided us with the top 100 most-cited publications in PD research, from which we took the following information: general trend of publication, year of publication, nation/region, institution, journal, author, and keywords. VOSviewer (version 1.6.18) and Excel (version 2016) were used for information analysis. Through a standardized search, we ultimately found 1019 papers in the field of PD research, from which we extracted the 100 articles that had received the highest citations. The articles were published between 1949 and 2016. The United States is a major contributor to PD research (n = 67). The University of California, Los Angeles, was the institution with the largest number of articles (n = 11). These articles were published in 16 journals, with the largest number appearing in the Journal of Urology (n = 47). The author with the most articles was Levine LA (n = 9). Gelbard MK’s articles had the highest citation frequency (n = 1158). Erectile dysfunction (n = 19) was the keyword with the highest frequency, indicating that PD-related erectile dysfunction was the leading focus of research in this field. Most of the keywords that have appeared in the past decade are related to the clinical treatment of PD. Therefore, we believe that improving patients’ erectile function to the greatest extent in clinical treatment is the frontier and hot spot of future research.

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Fig. 1: The development trend and geographical distribution of PD in scientific research.
Fig. 2: Co-occurrence analysis of keywords.

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Data availability

The data of “the top 100 most-cited articles in PD research” used to support the findings of this study are included within the supplementary information file.

References

  1. Musitelli S, Bossi M, Jallous H. A brief historical survey of “Peyronie’s disease”. J Sex Med. 2008;5:1737–46.

    Article  PubMed  Google Scholar 

  2. Lutman M. Bibliometric analysis as a measure of scientific output. Br J Audiol. 1992;26:323–4.

    Article  CAS  PubMed  Google Scholar 

  3. Hirsch JE. An index to quantify an individual’s scientific research output. Proc Natl Acad Sci USA 2005;102:16569–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Moed HF. New developments in the use of citation analysis in research evaluation. Arch Immunol Ther Exp. 2009;57:13–18.

    Article  Google Scholar 

  5. Godin B. On the origins of bibliometrics. Scientometrics. 2006;68:109–33.

    Article  Google Scholar 

  6. Gelbard MK, Dorey F, James K. The natural history of Peyronie’s disease. J Urol. 1990;144:1376–9.

    Article  CAS  PubMed  Google Scholar 

  7. Mulhall JP, Schiff J, Guhring P. An analysis of the natural history of Peyronie’s disease. J Urol. 2006;175:2115–8.

    Article  PubMed  Google Scholar 

  8. Mulhall JP, Creech SD, Boorjian SA, Ghaly S, Kim ED, Moty A, et al. Subjective and objective analysis of the prevalence of Peyronie’s disease in a population of men presenting for prostate cancer screening. J Urol. 2004;171:2350–3.

    Article  PubMed  Google Scholar 

  9. Schwarzer U, Sommer F, Klotz T, Braun M, Reifenrath B, Engelmann U. The prevalence of Peyronie’s disease: results of a large survey. BJU Int. 2001;88:727–30.

    Article  CAS  PubMed  Google Scholar 

  10. Lindsay MB, Schain DM, Grambsch P, Benson RC, Beard CM, Kurland LT. The incidence of Peyronie’s disease in Rochester, Minnesota, 1950 through 1984. J Urol. 1991;146:1007–9.

    Article  CAS  PubMed  Google Scholar 

  11. Gelbard M, Goldstein I, Hellstrom WJ, McMahon CG, Smith T, Tursi J, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190:199–207.

    Article  CAS  PubMed  Google Scholar 

  12. Devine CJ Jr, Horton CE. Surgical treatment of Peyronie’s disease with a dermal graft. J Urol. 1974;111:44–9.

    Article  PubMed  Google Scholar 

  13. El-Sakka AI, Hassoba HM, Pillarisetty RJ, Dahiya R, Lue TF. Peyronie’s disease is associated with an increase in transforming growth factor-beta protein expression. J Urol. 1997;158:1391–4.

    Article  CAS  PubMed  Google Scholar 

  14. Ralph D, Gonzalez-Cadavid N, Mirone V, Perovic S, Sohn M, Usta M, et al. The management of Peyronie’s disease: evidence-based 2010 guidelines. J Sex Med. 2010;7:2359–74.

    Article  PubMed  Google Scholar 

  15. Nehra A, Alterowitz R, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh JJ, et al. Peyronie’s disease: AUA guideline. J Urol. 2015;194:745–53.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Nelson CJ, Diblasio C, Kendirci M, Hellstrom W, Guhring P, Mulhall JP. The chronology of depression and distress in men with Peyronie’s disease. J Sex Med. 2008;5:1985–90.

    Article  PubMed  Google Scholar 

  17. Smith JF, Walsh TJ, Conti SL, Turek P, Lue T. Risk factors for emotional and relationship problems in Peyronie’s disease. J Sex Med. 2008;5:2179–84.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Levine LA, Burnett AL. Standard operating procedures for Peyronie’s disease. J Sex Med. 2013;10:230–44.

    Article  PubMed  Google Scholar 

  19. Levine LA, Merrick PF, Lee RC. Intralesional verapamil injection for the treatment of Peyronie’s disease. J Urol. 1994;151:1522–4.

    Article  CAS  PubMed  Google Scholar 

  20. Levine LA, Larsen SM. Surgery for Peyronie’s disease. Asian J Androl. 2013;15:27–34.

    Article  PubMed  Google Scholar 

  21. Levine LA, Newell M, Taylor FL. Penile traction therapy for treatment of Peyronie’s disease: a single-center pilot study. J Sex Med. 2008;5:1468–73.

    Article  PubMed  Google Scholar 

  22. Abdel Raheem A, Johnson M, Ralph D, Garaffa G. Collagenase clostridium histolyticum: a novel medical treatment for Peyronie’s disease. Minerva Urol Nefrol. 2018;70:380–5.

    Article  PubMed  Google Scholar 

  23. Dhillon S. Collagenase clostridium histolyticum: a review in Peyronie’s disease. Drugs. 2015;75:1405–12.

    Article  CAS  PubMed  Google Scholar 

  24. Gelbard MK, Lindner A, Kaufman JJ. The use of collagenase in the treatment of Peyronie’s disease. J Urol. 1985;134:280–3.

    Article  CAS  PubMed  Google Scholar 

  25. Levine LA, Cuzin B, Mark S, Gelbard MK, Jones NA, Liu G, et al. Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie’s disease: a phase 3 open-label study. J Sex Med. 2015;12:248–58.

    Article  PubMed  Google Scholar 

  26. Chung E, Ralph D, Kagioglu A, Garaffa G, Shamsodini A, Bivalacqua T, et al. Evidence-based management guidelines on Peyronie’s disease. J Sex Med. 2016;13:905–23.

    Article  PubMed  Google Scholar 

  27. Pryor JP, Ralph DJ. Clinical presentations of Peyronie’s disease. Int J Impot Res. 2002;14:414–7.

    Article  CAS  PubMed  Google Scholar 

  28. Rosen R, Catania J, Lue T, Althof S, Henne J, Hellstrom W, et al. Impact of Peyronie’s disease on sexual and psychosocial functioning: qualitative findings in patients and controls. J Sex Med. 2008;5:1977–84.

    Article  PubMed  Google Scholar 

  29. Levine LA, Benson J, Hoover C. Inflatable penile prosthesis placement in men with Peyronie’s disease and drug-resistant erectile dysfunction: a single-center study. J Sex Med. 2010;7:3775–83.

    Article  PubMed  Google Scholar 

  30. Palmieri A, Imbimbo C, Longo N, Fusco F, Verze P, Mangiapia F, et al. A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy for the treatment of Peyronie’s disease. Eur Urol. 2009;56:363–9.

    Article  PubMed  Google Scholar 

  31. Gontero P, Di Marco M, Giubilei G, Bartoletti R, Pappagallo G, Tizzani A, et al. Use of penile extender device in the treatment of penile curvature as a result of Peyronie’s disease. Results of a phase II prospective study. J Sex Med. 2009;6:558–66.

    Article  PubMed  Google Scholar 

  32. Gelbard M, Lipshultz LI, Tursi J, Smith T, Kaufman G, Levine LA. Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie disease [published correction appears in J Urol. 2012;188:678]. J Urol. 2012;187:2268–74.

    Article  CAS  PubMed  Google Scholar 

  33. Jordan GH. The use of intralesional clostridial collagenase injection therapy for Peyronie’s disease: a prospective, single-center, non-placebo-controlled study. J Sex Med. 2008;5:180–7.

    Article  PubMed  Google Scholar 

  34. Abern MR, Larsen S, Levine LA. Combination of penile traction, intralesional verapamil, andoral therapies for Peyronie’s disease [published correction appears in J Sex Med. 2012;9:945]. J Sex Med. 2012;9:288–95.

    Article  CAS  PubMed  Google Scholar 

  35. Shirazi M, Haghpanah AR, Badiee M, Afrasiabi MA, Haghpanah S. Effect of intralesional verapamil for treatment of Peyronie’s disease: a randomized single-blind, placebo-controlled study. Int Urol Nephrol. 2009;41:467–71.

    Article  CAS  PubMed  Google Scholar 

  36. Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, Myers L, Sikka SC, et al. Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie’s disease. J Urol. 2006;176:394–8.

    Article  CAS  PubMed  Google Scholar 

  37. Castiglione F, Hedlund P, Van der Aa F, Bivalacqua TJ, Rigatti P, Van Poppel H. et al. Intratunicalinjection of human adipose tissue-derived stem cells prevents fibrosis and is associated withimproved erectile function in a rat model of Peyronie’s disease [published correction appears in Eur Urol. 2013;64:e21]. Eur Urol. 2013;63:551–60.

    Article  CAS  PubMed  Google Scholar 

  38. Rolle L, Ceruti C, Timpano M, Sedigh O, Destefanis P, Galletto E, et al. A new, innovative, lengthening surgical procedure for Peyronie’s disease by penile prosthesis implantation with double dorsal-ventral patch graft: the “sliding technique”. J Sex Med. 2012;9:2389–95.

    Article  PubMed  Google Scholar 

  39. Kalsi J, Minhas S, Christopher N, Ralph D. The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie’s disease. BJU Int. 2005;95:1029–33.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by Sichuan Science and Technology Program (No. 2023NSFSC1799) and Science and Technology Development Fund of Hospital of Chengdu University of Traditional Chinese Medicine (Nos. 21ZS05 and 22ZL13).

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DG was responsible for writing and revising manuscripts. YS provided research methods and design. BT and ZM collected the data. YS and DChen examined the data. XY, GL, and DChang provided suggestions for the revision of the manuscript. DChang provided the topic selection for the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Degui Chang.

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Gao, D., Shen, Y., Tang, B. et al. The 100 most-cited publications on Peyronie’s disease: a bibliometric analysis and visualization study. Int J Impot Res 36, 110–117 (2024). https://doi.org/10.1038/s41443-023-00703-7

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