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The therapeutic effect of ALT-711 on erectile function in rats treated with high-level AGEs (advanced glycation end products) containing diet

International Journal of Impotence Research volume 34, pages 222–228 (2022)Cite this article

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A Correction to this article was published on 04 March 2022

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Abstract

To investigate, if advanced glycation end products (AGEs) are involved in erectile dysfunction (ED) and also ALT-711, a cross-link breaker of AGEs, has the therapeutic potential against the development of ED in rats treated with high concentrated AGEs including food. For this purpose, 30 male Harlan Spraque-Dawley rats randomly were divided into three groups; (1) control rats treated with regular diet, (2) rats treated with high-level of AGE specific diet for 6 months, and (3) rats having AGE-diet treated with ALT-711 for the final 3 months of 6 months of AGE-diet period. Erectile response to cavernosal nerve stimulation (CNS), protein expression of neuronal nitric oxide synthase (nNOS) and levels of AGEs, Malondialdehyde (MDA), cyclic guanosine monophosphate (cGMP) were determined in penile tissues. Erectile responses to CNS and penile nNOS and cGMP content were significantly reduced, while AGEs and MDA were elevated in penises of Group-2. Treatment with ALT-711 reversed ED and depletion of both nNOS and cGMP. Additionally, ALT-711 treatment reduced penile tissue AGEs and MDA expression. In present study: rats without any co-morbidity such as diabetes mellitus (DM) and chronic renal failure (CRF) were treated with high-level AGEs containing food. Our results suggest that ALT-711 may be an interesting and promising approach in the treatment of AGEs-related ED.

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Fig. 1: Cavernosal advanced glycation end product (5-HMF) and MDA levels.
Fig. 2: Cavernosal cGMP levels.
Fig. 3: Cavernosal nNOS protein expression.
Fig. 4: The voltage depending erectile response.

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Acknowledgements

This work was supported by the Akdeniz University Research Foundation.

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Authors and Affiliations

  1. Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, Turkey

    N. Gurbuz

  2. Department of Urology, Section of Andrology, School of Medicine, Akdeniz University, Antalya, Turkey

    R. Gurkan, A. Ender Caylan & M. F. Usta

  3. Health Vocational School, Bilim University, Antalya, Turkey

    S. Surmen Usta

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  1. N. Gurbuz
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Correspondence to M. F. Usta.

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The original online version of this article was revised to correct author name E. Ceylan to A. Ender Caylan.

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Gurbuz, N., Gurkan, R., Ender Caylan, A. et al. The therapeutic effect of ALT-711 on erectile function in rats treated with high-level AGEs (advanced glycation end products) containing diet. Int J Impot Res 34, 222–228 (2022). https://doi.org/10.1038/s41443-021-00417-8

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