Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

The application of superselective adrenal artery embolization in primary aldosteronism: evaluation, challenges, and response to Mr. Cabrelle and his team

Hypertension Research (2024)Cite this article

We would like to extend our heartfelt gratitude to Giulio Cabrelle and his colleagues for their valuable correspondence. We greatly appreciate their keen interest in our research and thorough examination of our paper. We also wish to express our thanks to the editorial board for granting us the opportunity for extensive discussions. After meticulously reviewing and deliberating upon the various opinions raised by Giulio Cabrelle and his team, we are pleased to provide the following responses.

First and foremost, we would like to provide further clarification on the inclusion criteria for superselective adrenal artery embolization (SAAE) in primary aldosteronism (PA). After diagnosing patients with PA at our hypertension center, and conducting thorough assessments, we ensure each patient is fully informed about the treatment options available. They are provided with a comprehensive overview of the advantages and disadvantages of each approach before we arrive at a definitive treatment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Heinrich DA, Adolf C, Holler F, Lechner B, Schneider H, Riester A, et al. Adrenal insufficiency after unilateral adrenalectomy in primary aldosteronism: long-term outcome and clinical impact. J Clin Endocrinol Metab. 2019;104:5658–64.

    Article  PubMed  Google Scholar 

  2. Hokotate H, Inoue H, Baba Y, Tsuchimochi S, Nakajo M. Aldosteronomas: experience with superselective adrenal arterial embolization in 33 cases. Radiology. 2003;227:401–6.

    Article  PubMed  Google Scholar 

  3. Zhang H, Li Q, Liu X, Zhao Z, He H, Sun F, et al. Adrenal artery ablation for primary aldosteronism without apparent aldosteronoma: An efficacy and safety, proof-of-principle trial. J Clin Hypertens (Greenwich). 2020;22:1618–26.

    Article  PubMed  Google Scholar 

  4. Zhou Y, Liu Q, Wang X, Wan J, Liu S, Luo T, et al. Adrenal ablation versus mineralocorticoid receptor antagonism for the treatment of primary aldosteronism: a single-center prospective cohort study. Am J Hypertens. 2022;35:1014–23.

    Article  CAS  PubMed  Google Scholar 

  5. Zhao Z, Liu X, Zhang H, Li Q, He H, Yan Z, et al. Catheter-based adrenal ablation remits primary aldosteronism: a randomized medication-controlled trial. Circulation. 2021;144:580–82.

    Article  PubMed  Google Scholar 

  6. Sun F, Liu X, Zhang H, Zhou X, Zhao Z, He H, et al. Catheter-based adrenal ablation: an alternative therapy for patients with aldosterone-producing adenoma. Hypertens Res. 2023;46:91–9.

    Article  PubMed  Google Scholar 

  7. Rossi GP, Bisogni V, Bacca AV, Belfiore A, Cesari M, Concistre A, et al. The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism. Int J Cardiol Hypertens. 2020;5:100029.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Moran W, Goetz FC, Melby J, Zimmermann B, Kennedy BJ. Primary hyperaldosteronism without adrenal tumor. Am J Med. 1960;28:638–47.

    Article  CAS  PubMed  Google Scholar 

  9. George JM, Wright L, Bell NH, Bartter FC. The syndrome of primary aldosteronism. Am J Med. 1970;48:343–56.

    Article  CAS  PubMed  Google Scholar 

  10. Weinberger MH, Grim CE, Hollifield JW, Kem DC, Ganguly A, Kramer NJ, et al. Primary aldosteronism: diagnosis, localization, and treatment. Ann Intern Med. 1979;90:386–95.

    Article  CAS  PubMed  Google Scholar 

  11. Sukor N, Gordon RD, Ku YK, Jones M, Stowasser M. Role of unilateral adrenalectomy in bilateral primary aldosteronism: a 22-year single center experience. J Clin Endocrinol Metab. 2009;94:2437–45.

    Article  CAS  PubMed  Google Scholar 

  12. Dong H, Zou Y, He J, Deng Y, Chen Y, Song L, et al. Superselective adrenal arterial embolization for idiopathic hyperaldosteronism: 12-month results from a proof-of-principle trial. Catheter Cardiovasc Interv. 2021;97:976–81.

    Article  PubMed  Google Scholar 

  13. Qiu J, Li N, Xiong HL, Yang J, Li YD, Hu CK, et al. Superselective adrenal arterial embolization for primary aldosteronism without lateralized aldosterone secretion: an efficacy and safety, proof-of-principle study. Hypertens Res. 2023;46:1297–310.

    Article  CAS  PubMed  Google Scholar 

  14. Lai ZQ, Fu Y, Liu JW, Zhang HJ, Zhang H, Liang NP, et al. The impact of superselective adrenal artery embolization on renal function in patients with primary aldosteronism: a prospective cohort study. Hypertens Res. 2023 https://doi.org/10.1038/s41440-023-01503-8.

Download references

Author information

Authors and Affiliations

  1. The 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, China

    Ze-Qun Lai & Yi-Fei Dong

  2. Jiangxi Key Laboratory of Molecular Medicine, Jiangxi, China

    Yi-Fei Dong

Authors
  1. Ze-Qun Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yi-Fei Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yi-Fei Dong.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lai, ZQ., Dong, YF. The application of superselective adrenal artery embolization in primary aldosteronism: evaluation, challenges, and response to Mr. Cabrelle and his team. Hypertens Res (2024). https://doi.org/10.1038/s41440-024-01668-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41440-024-01668-w

Keyword

Search

Advanced search

Quick links