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Meta-analysis of preoperative oral nutritional supplements for patients with gastric cancer: East Asian experience

European Journal of Clinical Nutrition volume 74, pages 991–1000 (2020)Cite this article

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Abstract

Whether it is beneficial to give preoperative oral nutritional supplements (P-ONS) to gastric cancer (GC) patients is still inconclusive. This study aimed to systematically explore the effectiveness and safety of P-ONS in GC patients. The PubMed, EMBASE, Medline, Cochrane Library, Chinese Biomedicine Literature Database (SinoMed), Chinese Scientific Journal Database (VIP), Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases were searched to identify relevant literature. A total of 11 randomized controlled trials (1183 patients) were included. Meta-analysis showed significantly lower levels of white blood cells (MD, −0.65; 95% CI, −1.01 to −0.30; P = 0.0003) and C-reactive protein (MD, −0.24; 95% CI, −0.31 to −0.16; P < 0.00001) in the P-ONS group than those in the routine diet group. Compared with the routine diet group, the P-ONS group had higher levels of albumin (MD, 1.63; 95% CI, 0.40–2.87; P = 0.010), IgG (MD, 0.65; 95% CI, 0.44–0.86; P < 0.00001), IgA (MD, 0.20; 95% CI, 0.02–0.37; P = 0.03), CD4+ (MD, 2.02; 95% CI, 0.82–3.22; P = 0.001) and CD4+/CD8+ (MD, 0.07; 95% CI, 0.02–0.12; P = 0.008). However, there were no significant differences (P > 0.05) in terms of prealbumin (P = 0.08), IgM (P = 0.25), postoperative complications (P = 0.18), and body weight (P = 0.25) between the two groups. For gastric cancer patients with nutritional risk, preoperative oral nutritional supplements for 5–7 days may effectively reduce the postoperative inflammatory response, enhance immune function and improve the nutritional status of patients.

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Authors and Affiliations

  1. West China School of Nursing, Sichuan University, 610041, Chengdu, Sichuan Province, China

    Xinrong Chen, Xingxia Zhang & Ka Li

  2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan Province, China

    Kun Yang

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Contributions

Conceptualization and formal analysis: CX, YK. Data curation, software and writing—original draft: CX, ZX. Project administration and resources: LK. Supervision and writing—review and editing: LK, YK.

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Correspondence to Ka Li.

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Because this was a meta-analysis that involved no people or animals, the need for ethics approval was waived.

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Chen, X., Yang, K., Zhang, X. et al. Meta-analysis of preoperative oral nutritional supplements for patients with gastric cancer: East Asian experience. Eur J Clin Nutr 74, 991–1000 (2020). https://doi.org/10.1038/s41430-019-0483-0

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