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Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia

Cancer Gene Therapy volume 27, pages 1–14 (2020)Cite this article

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Abstract

Relapsed and refractory acute myeloid leukemia (R/R AML) has complicated pathogenesis. Its treatment is complicated, and the prognosis is poor. So far, there is no consensus on what is the optimal treatment strategy. With the deepening of research, new chemotherapy regimens, new small molecule inhibitors, and immunotherapy have been increasingly applied to clinical trials, providing more possibilities for the treatment of R/R AML. The most effective treatment for patients who achieve complete remission after recurrence is still sequential conditioning therapy followed by allogeneic hematopoietic cell transplantation. Finding the best combination of treatments is still an important goal for the future.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81500118 and 61501519), the China Postdoctoral Science Foundation funded project (Project No. 2016M600443), and the Jiangsu Province Postdoctoral Science Foundation funded project (Project No.1701184B).

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Authors and Affiliations

  1. Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China

    Longzhen Cui, Tingting Qian, Liang Quan, Xu Ye, Ying Pang & Lin Fu

  2. Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China

    Longzhen Cui & Yan Liu

  3. Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China

    Longzhen Cui & Lin Fu

  4. Translational Medicine Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China

    Longzhen Cui, Tingting Qian, Liang Quan & Lin Fu

  5. Department of Medicine, William Beaumont Hospital, Royal Oak, MI, 48073, USA

    Yifan Pang

  6. Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Zhiheng Cheng

  7. Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Yifeng Dai

  8. Department of Biomedical Engineering, Chinese PLA General Hospital, 100853, Beijing, China

    Jinlong Shi

  9. Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, 100191, Beijing, China

    Xiaoyan Ke

  10. Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

    Depei Wu

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  1. Longzhen Cui
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Cui, L., Liu, Y., Pang, Y. et al. Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia. Cancer Gene Ther 27, 1–14 (2020). https://doi.org/10.1038/s41417-019-0119-5

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