Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • General
  • Published:

Trigeminal neuralgia and trigeminal neuropathic pain

Abstract

It is very important that the dental team are aware of the varied presentations of pain in the mouth, face and other parts of the trigeminal region which are not directly caused by teeth or oral structures. Our understanding of underlying causes in this complex area is evolving. Ultimately, patients who present with what may at first seem to be oral or dental problems will require specialist input in secondary care with potential for use of systemic medications. This article reviews the common non-dental pains encountered in the orofacial region related to dysfunction of the trigeminal nerve.

Key points

  • It can be challenging to differentiate between dental and non-dental causes of orofacial pain related to dysfunction of the trigeminal nerve.

  • Practitioners in primary care need to know how patients with these conditions may present in order to take an appropriate pain history as this is often crucial in deciding on a likely diagnosis.

  • While practitioners may not be involved in the definitive management of these patients, they can assist through definitive exclusion of a dental cause, timely onward referral and recognition of psychosocial factors in some of these conditions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. International Headache Society. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018; 38: 1-211.

  2. Koopman J, Dieleman J, Huygen F, de Mos M, Martin C G, Sturkenboom M C. Incidence of facial pain in the general population. Pain 2009; 147: 122-127.

  3. Maarbjerg S, Wolfram F, Heinskou T B et al. Persistent idiopathic facial pain - a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI. Cephalalgia 2017; 37: 1231-1240.

  4. Ziegeler C, Beikler T, Gosau M, May A. Idiopathic Facial Pain Syndromes - An Overview and Clinical Implications. Dtsch Arztebl Int 2021; 18: 81-87.

  5. Taiminen T, Kuusalo L, Lehtinen L et al. Psychiatric (axis 1) and personality (axis 11) disorders in patients with burning mouth syndrome or atypical facial pain. Scand J Pain 2011; 2: 155-160.

  6. Ziegeler C, Brauns G, May A. Characteristics and natural disease history of persistent idiopathic facial pain, trigeminal neuralgia, and neuropathic facial pain. Headache 2021; 61: 1441-1451.

  7. Forssell H, Tenovuo O, Silvoniemi P, Jaaskelainen S K. Differences and similarities between atypical facial pain and trigeminal neuropathic pain. Neurology 2007; 69: 1451-1459.

  8. Ziegeler C, Schulte L H, May A. Altered trigeminal pain processing on brainstem level in persistent idiopathic facial pain. Pain 2021; 162: 1374-1378.

  9. Hassona Y, El-Ma'aita A, Amarin J, Taee A Al. Diagnostic delay and suboptimal management in persistent idiopathic facial pain and persistent dentoalveolar pain; a cross-sectional study. Oral Surg Oral Med Oral Pathol Oral Radiol 2019; 127: 498-503.

  10. Breckons M, Bissett S M, Exley C, Araujo-Soares V, Durham J. Care Pathways in Persistent Orofacial Pain: Qualitative Evidence from the DEEP Study. JDR Clin Trans Res 2017; 2: 48-57.

  11. International Headache Society. International Classification of Orofacial Pain, 1st edition (ICOP). Cephalalgia 2020; 40: 129-221.

  12. Forssell H, Jääskeläinen S, List T, Svensson P, Baad-Hansen L. An update on pathophysiological mechanisms related to idiopathic oro-facial pain conditions with implications for management. J Oral Rehabil 2015; 42: 300-322.

  13. Miura A, Tu T T, Shinohara Y et al. Psychiatric comorbidities in patients with Atypical Odontalgia. J Psychosom Res 2018; 104: 35-40.

  14. Zagury J G, Eliav E, Heir G M et al. Prolonged gingival cold allodynia: a novel finding in patients with atypical odontalgia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 312-319.

  15. Pigg M, List T, Abul-Kasim K, Maly P, Petersson A. A comparative analysis of magnetic resonance imaging and radiographic examinations of patients with atypical odontalgia. J Oral Facial Pain Headache 2014; 28: 233-242.

  16. Malacarne A, Spierings E L, Lu C, Maloney G E. Persistent Dentoalveolar Pain Disorder: A Comprehensive Review. J Endod 2018; 44: 206-211.

  17. Wu S, Zhang W, Yan J, Noma N, Young A, Yan Z. Worldwide prevalence estimates of burning mouth syndrome: A systematic review and meta-analysis. Oral Dis 2022; 28: 1431-1440.

  18. Chmieliauskaite M, Stelson E A, Epstein J B et al. Consensus agreement to rename burning mouth syndrome and improve International Classification of Diseases-11 disease criteria: an international Delphi study. Pain 2021; 162: 2548-2557.

  19. Currie C C, Ohrbach R, De Leeuw R et al. Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome. Pain 2022; 163: 691-692.

  20. Lopez-Jornet P, Molino Pagan D, Andujar Mateos P, Rodriguez Agudo C, Pons-Fuster A. Circadian rhythms variation of pain in burning mouth syndrome. Geriatr Gerontol Int 2015; 15: 490-495.

  21. Grushka M, Epstein J, Gorsky M. Burning Mouth Syndrome. Am Fam Physician 2002; 65: 615-620.

  22. Bender S D. Burning Mouth Syndrome. Dent Clin North Am 2018; 62: 585-596.

  23. Jääskeläinen S K, Woda A. Burning mouth syndrome. Cephalalgia 2017; 37: 627-647.

  24. Jääskeläinen S K. Is burning mouth syndrome a neuropathic pain condition? Pain 2018; 159: 610-613.

  25. McMillan R, Forssell H, Buchanan J A, Glenny A-M, Weldon J C, Zakrzewska J M. Interventions for treating burning mouth syndrome. Cochrane Database Syst Rev 2016; DOI: 10.1002/14651858.CD002779.pub3.

  26. Nixdorf D R, Moana-Filho E J, Law A S, McGuire L A, Hodges J S, John M T. Frequency of nonodontogenic pain after endodontic therapy: a systematic review and meta-analysis. J Endod 2010; 36: 1494-1498.

  27. Van der Cruyssen F, Peeters F, De Laat A, Jacobs R, Politis C, Renton T. Prognostic factors, symptom evolution, and quality of life of posttraumatic trigeminal neuropathy. Pain 2022; 163: 557-571.

  28. Benoliel R, Zadik Y, Eliav E, Sharav Y. Peripheral painful traumatic trigeminal neuropathy: clinical features in 91 cases and proposal of novel diagnostic criteria. J Orofac Pain 2012; 26: 49-58.

  29. Renton T, Yilmaz Z. Profiling of patients presenting with posttraumatic neuropathy of the trigeminal nerve. J Orofac Pain 2011; 25: 333-344.

  30. Benoliel R, Teich S, Eliav E. Painful Traumatic Trigeminal Neuropathy. Oral Maxillofac Surg Clin North Am 2016; 28: 371-380.

  31. Renton T. Oral surgery II: Part 5. Chronic orofacial pain. Br Dent J 2017; 223: 826-836.

  32. Cruccu G, Di Stefano G, Truini A. Trigeminal Neuralgia. N Engl J Med 2020; 383: 754-762.

  33. Jones M R, Urits I, Ehrhardt K P et al. A Comprehensive Review of Trigeminal Neuralgia. Curr Pain Headache Rep 2019; 23: 74.

  34. Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia - diagnosis and treatment. Cephalgia 2017; 37: 648-657.

  35. Di Stefano G, Maarbjerg S, Truini A. Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. J Head Pain 2019; 20: 20.

  36. Royal College of Surgeons of England. Guidelines for the Management of Trigeminal Neuralgia Royal College of Surgeons of England. 2021. Available at https://www.rcseng.ac.uk/-/media/files/rcs/fds/guidelines/trigemina-neuralgia-guidelines_2021_v4.pdf (accessed January 2024).

  37. Nova C V, Zakrzewska J M, Baker S R, Riordain R N. Treatment Outcomes in Trigeminal Neuralgia - A Systematic Review of Domains, Dimensions and Measures. World Neurosurg X 2020; 6: 100070.

Download references

Author information

Authors and Affiliations

Authors

Contributions

Kevin Ryan wrote the following sections: persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; burning mouth syndrome; and painful post-traumatic trigeminal neuropathy. Alexander Crighton wrote the introduction and the section trigeminal neuralgia.

Corresponding author

Correspondence to Kevin Ryan.

Ethics declarations

The authors declare no conflicts of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ryan, K., Crighton, A. Trigeminal neuralgia and trigeminal neuropathic pain. Br Dent J 236, 323–328 (2024). https://doi.org/10.1038/s41415-024-7068-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41415-024-7068-6

Search

Quick links