Abstract
Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.
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Acknowledgements
AAT was supported, in part, by research funding from the NIH-NCI Cancer Center Support Grant (P30-CA016059; PI: Gordon Ginder, MD).
Author contributions
AAT, developed the idea and wrote the paper. AC, developed the idea and wrote the paper. JZ, developed the idea and wrote the paper. JR, developed the idea and wrote the paper. SKH, developed the idea and wrote the paper.
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The authors declare that they have no conflict of interest.
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Toor, A.A., Chesney, A., Zweit, J. et al. A dynamical systems perspective on chimeric antigen receptor T-cell dosing. Bone Marrow Transplant 54, 485–489 (2019). https://doi.org/10.1038/s41409-018-0329-8
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DOI: https://doi.org/10.1038/s41409-018-0329-8