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Epigenetics behind tumor immunology: a mini review

Oncogene volume 42, pages 2932–2938 (2023)Cite this article

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Abstract

Immunogenic- and immune-therapies have become hot spots in the treatment of cancer. Although promising, these strategies are frequently associated with innate or acquired resistance, calling for combined targeting of immune inhibitory signals. Epigenetic therapy is attracting considerable attention as a combination partner for immune-based therapies due to its role in molding the state and fate of cancer and immune cells in the tumor microenvironment. Here, we describe epigenetic dysregulations in cancer, with a particular focus on those related to innate immune signaling and Type I interferons, and emphasize opportunities and current efforts to translate this knowledge into treatment regimens with improved clinical benefit.

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Fig. 1
Fig. 2: Intriguing epigenetic strategies to boost immunotherapy efficacy.

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Acknowledgements

MM is supported by the AIRC-FIRC fellowship n. 25558.

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Authors and Affiliations

  1. Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168, Rome, Italy

    Martina Musella, Nicoletta Manduca, Ester Maccafeo & Antonella Sistigu

  2. Fondazione Policlinico Universitario ‘A. Gemelli’ - Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168, Rome, Italy

    Antonella Sistigu

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AS conceived the review. AS and MM wrote the manuscript with constructive input from all authors. NM and EM prepared display items under the supervision of MM. All authors approved the final version of the article and figures.

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Correspondence to Antonella Sistigu.

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Musella, M., Manduca, N., Maccafeo, E. et al. Epigenetics behind tumor immunology: a mini review. Oncogene 42, 2932–2938 (2023). https://doi.org/10.1038/s41388-023-02791-7

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