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Initialization of epithelial cells by tumor cells in a metastatic microenvironment

Oncogene volume 39, pages 2638–2640 (2020)Cite this article

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Fig. 1: CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.
Fig. 2: Identified CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.

References

  1. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2002;2:563–72.

    Article  CAS  Google Scholar 

  2. Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2012;481:85–9.

    Article  CAS  Google Scholar 

  3. Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, et al. Metastatic-niche labelling reveals parenchymal cells with stem features. Nature. 2019;572:603–8.

    Article  CAS  Google Scholar 

  4. Asselin-Labat ML. Cells tagged near an early spread of cancer. Nature. 2019;572:589–90.

    Article  CAS  Google Scholar 

  5. Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, et al. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells. 2008;26:364–71.

    Article  CAS  Google Scholar 

  6. Horiuchi A, Hayashi T, Kikuchi N, Hayashi A, Fuseya C, Shiozawa T, et al. Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene. Int J Cancer. 2012;131:1755–67.

    Article  CAS  Google Scholar 

  7. Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Investig. 2011;121:1298–312.

    Article  CAS  Google Scholar 

  8. Liu L, Qi L, Knifley T, Piecoro DW, Rychahou P, Liu J, et al. S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. J Biol Chem. 2019;294:7516–27.

    Article  CAS  Google Scholar 

  9. Herwig N, Belter B, Wolf S, Haase-Kohn C, Pietzsch J. Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells. J Cell Mol Med. 2016;20:825–35.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by grants from the Japan Ministry of Education, Culture, Science and Technology (nos. 24592510, 15K1079, and 19K09840), The Foundation of Osaka Cancer Research, The Ichiro Kanehara Foundation of the Promotion of Medical Science and Medical Care, The Foundation for the Promotion of Cancer Research, The Kanzawa Medical Research Foundation, and The Takeda Foundation for Medical Science.

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Authors and Affiliations

  1. National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, Japan

    Takuma Hayashi & Ikuo Konishi

  2. Department of Medical Laboratory, Shinshu University Hospital, Nagano, Japan

    Takuma Hayashi & Kenji Sano

  3. Genome Science Laboratory, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

    Hiroyuki Aburatani

  4. International Cancer Genome Consortium: ICGC, Tasmania, Australia

    Hiroyuki Aburatani

  5. Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan

    Nobuo Yaegashi

  6. Immediate Past President of Asian Society of Gynecologic Oncology, Tokyo, Japan

    Ikuo Konishi

Authors
  1. Takuma Hayashi
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  2. Kenji Sano
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  3. Hiroyuki Aburatani
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  4. Nobuo Yaegashi
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Contributions

TH and KS performed most of the experiments and coordinated the project; KS performed cell sorting and the flow cytometric analysis by BD FACSAriaâ„¢ III; TH performed xenograft studies for the micrometastasis model; TH, KS, and HA were involved in pathology assessments and the detection of CD90-positive stem-like cells; TH conceived the study and wrote the paper. NY and IK gave information on clinical medicine and oversaw the entire study.

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Correspondence to Takuma Hayashi.

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Hayashi, T., Sano, K., Aburatani, H. et al. Initialization of epithelial cells by tumor cells in a metastatic microenvironment. Oncogene 39, 2638–2640 (2020). https://doi.org/10.1038/s41388-020-1171-1

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  • DOI: https://doi.org/10.1038/s41388-020-1171-1

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