Abstract
Background
Obesity and metabolic syndrome (MetS) have been acknowledged to commonly co-exist and lead to increased risks of stroke, whereas the association between various BMI-based metabolic phenotypes and development of intracranial atherosclerotic stenosis (ICAS) remained controversial.
Methods
A total of 5355 participants were included from the Asymptomatic Polyvascular Abnormalities Community (APAC) study. Participants were categorized into six groups according to their body mass index (BMI) and MetS status. ICAS was assessed using transcranial Doppler (TCD) Ultrasonography. Logistic regression was employed to evaluate the association between BMI-based metabolic phenotypes and ICAS.
Results
704 participants were diagnosed with ICAS. Compared to the metabolic healthy normal weight (MH-NW) group, the metabolic unhealthy normal weight (MUH-NW) group demonstrated a higher risk of ICAS (full-adjusted odds ratio [OR], 1.91; 95% confidence interval [CI], 1.42–2.57), while no significant association was observed in the metabolic unhealthy obesity (MUO) group (full-adjusted OR, 1.07; 95% CI, 0.70–1.65) and other metabolic healthy groups regardless of BMI. The results were consistent across gender, age, smoking, alcohol intake, and physical activity subgroups.
Conclusion
The present study suggested that MUH-NW individuals had a significant association with increased risk of ICAS compared with MH-NW individuals.
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Data availability
The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
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Acknowledgements
We thank all the participants of the APAC study for their invaluable contributions.
Funding
This work was supported by National Key Research and Development Program of China (2022YFC3600600), Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University (CCMU2022ZKYXZ009), Beijing Natural Science Foundation Haidian original innovation joint fund (L222123), Fund for Young Talents of Beijing Medical Management Center (QML20230505), and the high-level public health talents (xuekegugan-02-47).
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Xinsheng Han, Guangxin Xia, Xingquan Zhao, and Anxin Wang designed the study. Xingquan Zhao and Anxin Wang recruited participants and conducted the study. Xue Xia and Anxin Wang conducted the statistical analysis. Xue Xia and Guangxin Xia wrote the first draft of the manuscript.
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Xia, X., Han, X., Xia, G. et al. Association between BMI-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study. Int J Obes (2024). https://doi.org/10.1038/s41366-024-01521-7
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DOI: https://doi.org/10.1038/s41366-024-01521-7