Abstract
In order to investigate the relationship between low serum IgG2 and anti-PS AB deficiency, we compared the IgGl and IgG2 AB responses of 16 G2D children (mean age-55 no) vaccinated with Hib PS vaccine with the responses of 51 healthy vaccinated controls (CON) (mean age=35 mo). Total AB responses to Hib PS (measured by Parr assay) were significantly lower in the G2D patients (P<.001, Table). The G2D subjects had significantly lower IgGl responses (measured by ELISA) than CON (P=.003) and, as expected, the G2D patients also had lower IgGZ responses (P<.001). 11/16 G2D patients (mean age=56 mo) have been vaccinated with PN PS vaccine. The IgG responses to P-3 and P-23 were lower than those of 17 vaccinated CON children (mean age=49 mo),(P<.03 and .09, respectively). Thus, G2D patients have deficient IgG antibody responses to Hib, and P-3 and P-23 PN PS. However, this deficiency is not necessarily related directly to low serum concentrations of IgG2 since G2D patients have deficient IgGl responses to Hib PS des~ite normal serum IgGl.
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Shackelford, P., Granoff, D. ANTIBODY (AB) RESPONSES OF IGG2 DEFICIENT (G2D) CHILDREN TO H. INFLUENZAE TYPE B (HIB) AND PNEUMOCOCCAL (PN) TYPES 3 (P-3) AND 23 (P-23) POLYSACCHARIDES (PS). Pediatr Res 21 (Suppl 4), 318 (1987). https://doi.org/10.1203/00006450-198704010-00904
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DOI: https://doi.org/10.1203/00006450-198704010-00904