Abstract
Ab to PRP are protective against Hib systemic infections, but infants of age <18 mo generally do not have an adequate Ab response to the current PRP vaccine. However, sequential injections of oligosaccharides coupled to diphtheria toxoid carriers (D-ol) can induce anti-PRP Ab in early infancy. The high titers are relatively transient, but a preliminary study showed that 6 infants given D-ol at age 2, 4, and 6 mo made a high-for-age and long-lived Ab response to an injection of PRP at age 9-11 mo.
These studies have been extended to show: (1) the phenomenon is consistent--26 of 27 D-ol-primed infants had an Ab rise with a geometric mean greatly exceeding that of unprimed infants; (2) a large response to the PRP “booster” can follow even a poor response to the D-ol priming; (3) while the response to D-ol is relatively high in IgG1/IgG2 ratio, the IgG2 tends to predominate in the response of infants to the PRP booster, as it does in the responses of adults; and (4) isoelectric focusing shows that the IgG response to D-ol consists of a relatively small number of B cell clones, that the response to the PRP booster occurs by restimulation of these clones, and that those clones with a low pI may be preferentially reactivated.
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Pichichero, M., Insel, R. & Anderson, P. ADULT-LIKE ANTIBODY (Ab) RESPONSES TO HAEMOPHILUS INFLUENZAE b (HIB) CAPSULAR POLYSACCHARIDE (PRP) VACCINE IN HUMAN INFANTS PRIMED WITH PROTEIN-OLIGOSACCHARIDE CONJUGATE VACCINES. Pediatr Res 21 (Suppl 4), 316 (1987). https://doi.org/10.1203/00006450-198704010-00893
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DOI: https://doi.org/10.1203/00006450-198704010-00893