Abstract
We had previously reported that serum levels of KS increased from birth, reached a plateau between 6-11 years of age and then rapidly declined to levels which were maintained throughout normal adulthood. The purpose of this study was to determine if serum levels of KS were correlated with the percentile height in children in the 6-11 year old age range, using an ELISA with a monoclonal antibody 1/20/5-D-4 to KS. Sera were obtained from 33 GENPEDS whose records had been screened and who had no evidence of autoimmune disease. Levels of KS (ng/ml ± SD) were higher in taller children (≥75th percentile) than shorter children (≤25th percentile): 632±122 vs. 480±126, (p<.007). Fourteen children with CD (<5th percentile) had KS values of 414±118 which were not significantly different from the shorter group of GENPEDS, p=O.11. In contrast, the CD group had KS values significantly different from the ≥75th percentile GENPEDS, p=0.001. KS values in 10 JRA children, ages 6-11, of varying percentile height prior to any steroid treatment were low, i.e. 451±98. Another group of JRA children, on steroids, had an even lower KS value; 399±83. These studies suggest that KS values are correlated not only with the height of the child but may also reflect alterations in cartilage proteoglycan metabolism in JRA which is accentuated by prednisone.
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Pachman, L., Hayford, J., Lynch, P. et al. COMPARISONS OF SERUM LEVELS OF KFRATAN SULFATE (KS) WITH HEIGHT IN AN OUTPATIENT PEDIATRIC POPULATION (GFNPFDS), CONSTITUTIONAL. GROWTH DELAY (CD), AND IN JUVENILE RHEUMATOID ARTHRITIS (JRA). Pediatr Res 21 (Suppl 4), 315 (1987). https://doi.org/10.1203/00006450-198704010-00889
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DOI: https://doi.org/10.1203/00006450-198704010-00889