Abstract
Neonatal urinary HVA and VMA (neuroblastoma markers) levels in filter paper samples were determined as part of a feasibility study on screening for neuroblastoma. Urine samples from 531 neonates were absorbed from diapers onto absorbent filter papers at the age of 2-144 hours. The samples were dried in room air and mailed to the laboratory. Urinary compounds were eluted from a 20 Cm2 section of each filter paper, an aliquot was used for urinary creatinine (UCr) determination by the Jaffe reaction and HVA and VMA were determined by automated capillary gas-chromatography. Mean UCr levels were higher before the age of 36 hours than after 36 hours (p=0.07). Mean HVA levels were lower before 24 hours than after 24 hours (p=0.02). Mean VMA levels were higher before 24 hours than after 24 hours (p=0.006) and before 36 hours compared to after 36 hours (p=0.006). No positive neuroblastoma cases were identified during this study, as expected.
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Tuchman, M., Robison, L., Fisher, E. et al. NEONATAL HOMOVANILLIC (HVA) AND VANILLYLMANDELIC (VMA) ACID LEVELS IN URINE SAMPLES COLLECTED ON FILTER PAPERS. Pediatr Res 21 (Suppl 4), 307 (1987). https://doi.org/10.1203/00006450-198704010-00837
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DOI: https://doi.org/10.1203/00006450-198704010-00837