Abstract
This study was undertaken to define both the acute and long-term effects of C on the IL-2 system. 10 children with ALL receiving standard C for 6-36 mos, 11 children with All off all C for 2-80 mos and 15 age-matched controls were studied. Responsiveness to IL-2 was determined by culturing activated T cells with human recombinant IL-2 with proliferation estimated by 3H-TdR incorporation. IL-2 production was quantitated in culture supernatants from phytohemagglutinin(PHA)-stimulated mononuclear cells(MNC). IL-2 receptor(IL-2R)expression was quantitated on PHA-stimulated MNC.
In conclusion, these results demonstrate that children with ALL receiving C have a significantly depressed IL-2 system. These results also show that although cessation of C allowed IL-2 responsiveness to normalize, the defects in IL-2 production and IL-2R expression persisted, suggesting that a substantial therapy-induced immunodeficiency may be among the late effects present in long-term survivors of ALL.
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Borzy, M., Ridgway, D., Parkman-Newton, C. et al. EFFECT OF MAINTENANCE CHEMOTHERAPY (C) FOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) ON INTERLEUKIN-2 (IL-2) PRODUCTION, RESPONSE AND RECEPTOR EXPRESSION. Pediatr Res 21 (Suppl 4), 296 (1987). https://doi.org/10.1203/00006450-198704010-00775
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DOI: https://doi.org/10.1203/00006450-198704010-00775