Abstract
From 12/80 to 7/85, 66 patients (pts) were hospitalized with diarrhea (D), including 4 in the nursery, and studied for rotavirus (RV) infection initially, during later D episodes, and periodically, a total of 2117 person-mos. Fecal samples were collected initially from all, during later D from 25, and q. 6 mos, a total of 376. Acute and convalescent sera were obtained from 62 and sera from most at 6-mos. intervals, a total of 424. During first D, 47 had RV and 19 had no RV in feces. (RV⊕were 1-22 mos, RV ⊖ 9 days-19 mos of age; two-thirds were boys.) 22 (47%) RV⊕pts had 27 episodes of D vs 5 (26%) RV⊖pts with 6 episodes (RV⊕0.2/yr vs RV ⊖0.11/yr), none severe. No feces showed RV antigen but 1 had fecal adenovirus. Acute sera of 9/47 (19%) of those RV⊕in their initial D vs 10/19 (57%) RV⊖had RV CF antibody (Ab) ≥ 1:2 (p=0.01, x2). 40/45 (89%) RV⊖pts vs only 3/17 (18%) RV⊖pts had ≥ 4-fold CF Ab rise during initial D (p=0.006, Fisher's). During follow-up, ≥ 4-fold rise in CE Ab was noted in 18/47 (38%) pts originally RV⊕vs 8/19 (42%) RV ⊖. Although RV ⊕pts had more episodes of D later, particularly at ≤ 36 mos of age (24 D in RV⊕ vs 4 in RV ⊖ p=.05 Fisher's), the frequency of RV infection and/or reinfection, as measured by Ab rise, was similar in both groups, confirming the universality of high frequency of RV infection. Since our reagents were group RV specific, we cannot state whether the infections were due to different subgroups or serotypes.
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Rodriguez, W., Kim, H., Brandt, C. et al. INCIDENCE OF ROTAVIRUS (RV) REINFECTION AND/OR INFECTION IN CHILDREN HOSPITALIZED WITH DIARRHEA: A PROSPECTIVE LONGITUDINAL STUDY. Pediatr Res 21 (Suppl 4), 286 (1987). https://doi.org/10.1203/00006450-198704010-00716
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DOI: https://doi.org/10.1203/00006450-198704010-00716