Abstract
In order ro determine the effect of MCT diet on “quality growth” (i.e. protein vs. fat deposition) we investigated the effect of feeding an MCT-enriched formula (Group I; n=8) vs. OMM (Group II; n=9) on oxidation (oxid.) and accretion (accr.) of energy, macronutrients and growth in 17 healthy VLBW infants combining macronutrient balance, indirect calorimetry and anthropometry. 14 studies were performed in Group I and 13 in Croup II. Clinical parameters and energy intake were comparable in both groups.
Results are demonstrated in the table (*p<0.01; *p≤0.05)
Oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory quotient (RQ) and weight gain did not differ in the two groups. The composition of weight gain indicated a higher percent of fat per gram weight gain in Group I (25.5%) than in Grp.II (14.7%). Protein accretion was similar.
Conclusions: 1) Although weight gain was similar in the infants fed either OMM or MCT formula, the composition of weight gain in the MCT group favoured more fat, presumably due to the higher fat intake and lower losses. 2) Similar VO2, VCO2 and RQ indicate a similar proportion of carbohydrate and fat oxidation. 3) Since MCT diet did not promote fat oxidation, we assume that part of MCT is diverted into the chain elongation pathway in the liver of the preterm infant.
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Aerde, J., Sauer, P., Heim, T. et al. COMPOSITION OF WEIGHT GAIN AND MACRONUTRIENT STORAGE IN VERY LOW BIRTH WEIGHT (VLBW) INFANTS FED OWW MOTHER'S MILK (OMM) OR MEDIUM-CHAIN-TRICLYCERIDE (MCT) ENRICHED FORMULA. Pediatr Res 21 (Suppl 4), 281 (1987). https://doi.org/10.1203/00006450-198704010-00681
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DOI: https://doi.org/10.1203/00006450-198704010-00681