Abstract
Antigliadin antibodies (AGA) have been proposed as a screening method for celiac disease. It has been questionable as to whether IgA or IgG AGA are more useful. We examined serum samples from 130 pediatric patients, including 16 with celiac disease. A direct ELISA assay was done for both IgA and IgG AGA. The result was expressed as the mean patient optical density (OD) minus the control (background produced by milk protein antibodies). The sensitivity and specificity of the assay is shown in the table. IgG AGA sensitivity specificity of the assay is shown in the table.
AGA were increased both in older patients (p<.002) and in the presence of celiac disease (IgG p<.0001, IgA p<.001). IgG AGA alone or the combination of both IgA and IgG are better predictors of celiac disease than IgA AGA.
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Tucker, N., Barghuthy, F., Kumar, V. et al. ANTIGLIADIN ANTIBODIES DETECTED BY ELISA AS A MARKER OF CHILDHOOD CELIAC DISEASE. Pediatr Res 21 (Suppl 4), 280 (1987). https://doi.org/10.1203/00006450-198704010-00676
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DOI: https://doi.org/10.1203/00006450-198704010-00676