Abstract
NNS improves weight gain and allows earlier hospital discharge of low birth weight (LBW) infants (Pediatrics 71:41, 1983). The improved weight gain could be due to more efficient nutrient digestion and absprption. Preduodenal lipases have a compensatory function in fat digestion during physiologic (developmental) or pathologic (cystic fibrosis, alchoholism related) pancreatic insufficiency (J Clin Invest 67:838, 1981; 73:374, 1984; Padietr Res 18:402, 1984 and Gestroenterol 1987, in press). We have therefore investigated whether NNS stimulates the secretion of these lipases in LBW infants. Two separate studies were conducted: 1) 9 infants (gest. age 30.5±0.8 wks, postnatal age 29±3 days) received gavage feeding (GF) with and without NNS, each infant being his/her own control. 2) 10 infants (gest. age 29.7±0.8 wks, postnatal age 32±5 days) were divided into two groups: 4 infants received GF without NNS and 6 infants received GF with NNS. Lipase activity was measured in gastric aspirates.
These data suggest, that increased secretion of lipases is not the cause of improved weight gain in infants fed by gavage with nonnutritive sucking. (Support: NIH grant HD 10823.)
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Smith, Y., Bernbaum, J., Hamosh, M. et al. NONNUTRITIVE SUCKINO(NNS) DOES NOT STIMULATE THE SECRETION OF LIN6UAL AND GASTRIC LIPASES IN PREMATURE INFANTS. Pediatr Res 21 (Suppl 4), 278 (1987). https://doi.org/10.1203/00006450-198704010-00663
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DOI: https://doi.org/10.1203/00006450-198704010-00663