Abstract
The adequacy of the recommended parenteral intakes of Zn and Cu was studied in 12 infants (X±SE: 3.3±1.4 mo, range 0.25-17 mo) who were NPO and who received TPN supplemented with Zn and Cu (100 μg/kg/d and 10 μg/kg/d, respectively) as recommended by AMA guidelines. Zn and Cu serum measurements and 24 hr balances were obtained at baseline, 1, and 2 wk. Results of the Zn and Cu determinations are shown.
Normal serum Zn: 52-163 μg/dl; normal serum Cu: 65-145 μg/dl)
Serum levels were low at baseline, 1 and 2 wk for Zn in 4/12, 3/12, and 0/6 infants and for Cu in 5/12, 3/12, and 1/6 infants, respectively. Balances were negative at baseline, 1 and 2 wk for Zn in 6/12, 2/12, and 1/6 infants and for Cu in 5/12, 1/12, and 0/6 infants, respectively. Only infants with intestinal drainage (i.e., nasogastric, ileostomy) were in negative balance at 1 and 2 wk. Conclusions: 1) These preliminary data suggest that the recommended parenteral Zn and Cu intakes are adequate for most infants. 2) Infants with intestinal drainage may require supplemental Zn and Cu. 3) Changes in Zn balances were not reflected in serum Zn levels.
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Shulrnan, R. ZINC AND COPPER BALANCE STUDIES IN INFANTS RECEIVING TOTAL PARENTERAL NUTRITION (TPN). Pediatr Res 21 (Suppl 4), 277 (1987). https://doi.org/10.1203/00006450-198704010-00661
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DOI: https://doi.org/10.1203/00006450-198704010-00661