Abstract
Hemolysis is a major factor contributing to increased bilirubin production and hyperbilirubinemia during biliary obstruction in the rat [Salomon, et al. J Pediatr Gastroenterol Nutr 5:806-810, 1986]. Tin-protoporphyrin (TP) inhibits heme oxygenase, which catalyzes the first step in the degradation of heme to bilirubin, derived from red blood cell breakdown. Therefore, we studied TP's effect on the elevations in the excretion rate of CO (VeCO), an index of bilirubin production, and the pliisma total bilirubin level ([B]), caused by ligation of the common bile duct in adult Wistar rats. At post-operative t=72 h and 96 h, experimental rats were injected SQ with 50 umoles TP/kg body weight.
By 120 hours after surgery, the VeCO had fallen by 23% and the [B] by 32% in TP-trented animals compared to no significant changes in the saline-treated controls. The inhibition of bilirubin production by TP in adult rats with surgically-created obstructive jaundice is an important factor in decreasing the hyperbilirublnemia of cholestasis in this model.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McMillan, J., Vreman, H. & Stevenson, D. TIN-PROTOPORPHYRIN DECREASES BILIRUBIN PRODUCTION AND HYPERBILIRUBINEMIA IN OBSTRUCTIVE JAUNDICE. Pediatr Res 21 (Suppl 4), 273 (1987). https://doi.org/10.1203/00006450-198704010-00634
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00634