Abstract
Previous studies indicate long chain fats have trophic effects on post-resection intestinal mucosal adaptation. We have previously shown that short term essential fatty acid (EFA) deficiency impairs normal post-resection mucosal hyperplasia, while 16, 16 dimethyl-PGE2 administration stimulates hyperplasia. The effect of increased dietary linoleic acid (LA) on promoting mucosal adaptation in resected, non-EFA deficient animals was evaluated. Ten Sprague-Dauley rats (5 w/o males) were pair-fed isocaloric diets containing 1% or 5% (LA) (w/w). After 2 weeks all animals underwent 70% proximal jejunoileal resection. Animals were then pair-fed for 14 days. Following sacrifice mucosal weight, protein, DNA, and sucrase activity were determined:
Protein levels were increased in all segments in 5% LA animals (p<.05). Similar results were seen for mucosal weight, DNA, and sucrase activity. Our results indicate 5% LA has “trophic” properties on post-resection mucosal adaptation similar to the effect of 16, 16 dimethyl-PGE2. In view of reports of increased dietary LA stimulating intestinal PGE2 synthesis, LA supplementation may exhibit its stimulatory effect via this mechanism.
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Hart, M., Park, J., Grandjean, C. et al. AUGMENTATION OF POST-RESECTION MUCOSAL HYPERPLASIA BY LINOLEIC ACID FEEDING. Pediatr Res 21 (Suppl 4), 269 (1987). https://doi.org/10.1203/00006450-198704010-00613
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DOI: https://doi.org/10.1203/00006450-198704010-00613