Abstract
The enhanced glucose turnover in the fetus of a diabetic gestation may exhaust fetal thiamine (T) stores. We examined by RbcTK assay the T status in the offspring of streptozotocin-diabetic rats (D) and their controls (C). After mating, D rats were randomly assigned to have either daily SC Insulin Lente IU(DIn) or NS. Immediately after birth a pooled blood sample from each litter was examined for glucose, insulin, and RbcTK.
Our study indicates that uncontrolled diabetic pregnancy can cause fetal thiamine deficiency, which may be responsible for some of the clinical features of the “infant of diabetic mother” syndrome.
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Berant, M., Berkowitz, D., Mandel, H. et al. ERYTHROCYTE TRANSKETOLASE ACTIVITY (RbcTK) IN THE OFFSPRIHG OF DIABETIC RATS. Pediatr Res 21 (Suppl 4), 264 (1987). https://doi.org/10.1203/00006450-198704010-00581
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DOI: https://doi.org/10.1203/00006450-198704010-00581