Abstract
Autoradiographic studies in rats have demonstrated specific localization of 1, 25 in hair follicle basal cells, whereas, in humans, the absence of 1, 25 nuclear binding is associated with alopecia. These observations suggest a role of 1, 25 in the regulation of the epidermal cells responsible for hair growth and/or differentiation. We hypothesized that in a species which demonstrates a mosaicism of hair growth, such as the sheep, there would be a similar mosaicism of 1, 25 receptor concentrations. We tested this hypothesis in nuclear receptors prepared by high salt extraction of a low salt crude nuclear fraction of wooly, flank skin (W) versus non-wooly, groin skin (NW).
3H-1, 25-Receptor complexes exhibit a 3.5S binding component that co-sedimented with the sheep intestinal receptor, bound to DNA-cellulose and eluted with 0.16H KCl. Scatchard analysis revealed the following equilibrium binding data:
Preliminary studies of neonatal skin indicate a similar mosaicism though receptor concentrations are generally twice that in the adult. These data represent the first demonstration of a cutaneous mosaicism of 1, 25 receptors in an animal species. The finding of increased 1, 25 receptor density in areas of wool production provides further evidence for a role of 1, 25 in the regulation of hair growth and/or differentiation.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ross, R., Florer, J. MOSAICISM OF SKIN 1,25 DIHYDROXYVITAM1N D3, (1,25) RECEPTORS IN THE ADULT AND NEONATAL SHEEPT INCREASED RECEPTOR DENSITY IN WOOLY SKIN. Pediatr Res 21 (Suppl 4), 253 (1987). https://doi.org/10.1203/00006450-198704010-00517
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00517