Abstract
We hypothesized that some infants of men with Kallmann's syndrome (genetically transmitted condition) would show deficiency of the neonatal gonadotropin and sex steroid surge demonstrated in normal infants. Most affected individuals are not identified until the onset of puberty is delayed. Accordingly, we evaluated seven infants fathered by men who became fertile after hormonal treatment for Kallmann's syndrome. Midline facial features and genital anatomy were normal in all. Blood was sampled through an indwelling line every 20 minutes from midnight to 2 AM for LH, FSH, and either estradiol (E2) and testosterone (T), prior to an LHRH test (100 mcg IV).
These data indicate that infants of kallmann's fathers have the gonadotropin and sex steriod surch shown for normal infants.
We conclude that either our infants do not have kallmann's syndrome, or the neonatal surge remains intact despite protential later loss of gonadotropin release.
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Rose, S., Cassorla, F. & Sherins, R. GONADOTKOP IN SURGE IN INFANTS OF MEN WITH KALLMANN'S SYNDROME. Pediatr Res 21 (Suppl 4), 253 (1987). https://doi.org/10.1203/00006450-198704010-00515
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DOI: https://doi.org/10.1203/00006450-198704010-00515