Abstract
Plasma SmC/IGFI concentrations do not correlate well with growth velocity of healthy infants and children, nor with linear growth rates of GH deficient patients during GH therapy. The aim of this study was to obtain quantitative information about the excretion of SmC/IGFI in timed urine collections obtained from children with normal and abnormal growth. 84 children (ages 2-17 years) collected 12 hour overnight urine specimens. Group I included healthy controls. Group II comprised children with height >−2 S.D., growth < 5 cms/year, and peak GH > 8 ng/ml to stimulii. Group III consisted of GH deficient children. 50 ml aliquots of urine were dialyzed and concentrated 50 fold by Iyophylization using a modification of the method of Hansen. SmC/IGFI. was measured by a radioimmunoassay (Nichols Institute). The quantity of SmC/IGFI excreted was standardized for weight (mU/kg).
Healthy children (Group I) excrete significantly greater amounts of SmC/IGFI than children with pathologic growth (groups II and III, p < .01). Pubertal and prepubertal children had similar quantities of SmC/IGFI.
Conclusion; Pathologically short children who are GH deficient or GH sufficient by standard provocative tests, excrete less urine SmC/IGFI than control subjects. Measurements of urine SmC/IGFI may increase our understanding about the interplay between this growth factor and GH, sex steroids and nutrition.
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Quattrin, T., Alblni, C. & Macgillivray, M. QUANTITATTON OF URINARY SOMATOMEDIN C (SmC/IGFI). Pediatr Res 21 (Suppl 4), 252 (1987). https://doi.org/10.1203/00006450-198704010-00510
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DOI: https://doi.org/10.1203/00006450-198704010-00510