Abstract
To correlate neuroendocrine changes with clinical response, 4 girls (4-7 yrs) and 1 boy age 6 with central precocious puberty were treated with D-His-A subcutaneously. D-His-A was given at a dose of 4 μg/kg/day for 4 mos; then, the dose was increased to 8 μg/kg/day. The children were serially studied at 0, 3, and 6 mos. Blood was analyzed for GH, LH, FSH q 20 min (1800-0600). GnRH (2.5 μg/kg IV) tests and response to D-His-A (usual treatment dose sc) were followed. Gonadal steroids fell to prepubertal range in the first 3 mos. Results of mean growth velocity (GV), GH, Somatomedin C, LH and FSH, GnRH and D-His-A Tests are shown:
Bone age advanced 6 mos/6 mos therapy. We conclude D-His-A at 4 μg/kg/day for 3 mos did not decrease growth velocities despite decreases in mean overnight GH, Somatomedin C and gonadal steroids. Mean overnight LH and FSH values showed stepwise decrease with higher doses of D-His-A. We suggest that children with D-His-A need a minimum of 8 μg/kg/day and that D-His-A response should be used to evaluate therapy rather than GnRH tests.
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Mendes, T., Foster, C., Hopwood, N. et al. NEUROENDOCRINE CHANGES WITH D His GnRH ANALOGUE (D-His-A). Pediatr Res 21 (Suppl 4), 251 (1987). https://doi.org/10.1203/00006450-198704010-00501
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DOI: https://doi.org/10.1203/00006450-198704010-00501