Abstract
Nitrendipine, a new long-acting calcium channel blocking agent, was used to treat hypertension in 8 children between 6 months and 17 years of age (mean=7.6±2.3 years). Seven of the children had renal disease and all subjects were previously treated with other antihypertensive agents. Systolic (SBP) and diastolic (DBP) blood pressure fell from a mean of 148 ±4/95±2 mmHg to 134±3/82±4 mmHg (p<0.02) one hour after an initial dose of 0.1 mg/kg. By 5 hours, SBP and DBP had fallen to 127±6/84±6 mmHg (p<0.05) in response to a total mean dose of 0.36 ±0.05 mg/kg. Seven of eight patients were continued on chronic N therapy. Long term data from these patients is as follows:
No significant changes in total or ionized calcium, BUN, or creatinine were noted. No adverse effects were observed. These data suggest that N is an effective agent for long term anti-hypertensive therapy in children.
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Wells, T., Sinaiko, A. NITRENDIPINE (N) TREATMENT OF HYPERTENSION: ACUTE AND LONG TERM EFFECTS IN CHILDREN. Pediatr Res 21 (Suppl 4), 243 (1987). https://doi.org/10.1203/00006450-198704010-00456
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DOI: https://doi.org/10.1203/00006450-198704010-00456