Abstract
The feasibility of noninvasive sampling of theophylline (TH) and caffeine (CF) into a novel Transdermal Collection System (TCS) has been studied in 14 pretermn infants (PI) on 1-3 occasions. The TCS induces the outward migration of drugs by Juxtaposing 2.54 cm2 of skin with a transfer medium (saline aguagel), containing a binding sink (activated charcoal). 14 PI (25-34 weeks gestation and 3-175 days old) who were receiving TH therapy had 4 TCS's placed on the back for 12 hours during which one or more routine plasma concentrations (Cp) were measured. Cp and the flux of TH ( < 50-1850 ng) and CF ( < 50--200 no) into each TCS were determined by HPLC. Apparent permeability coefficients (Kp) = (TCS-flux (ng/cm2/hr ) /aveCp during TCS placement) of any one PI showed little change over time once the PI was >2 wks old. Our Kp for CF ranged from .2-6*10−3 cm/hr and our Kp for TH (.2-8*10−3 cm/hr) overlap the range ( .8-1.4*10−3 cm/hr) derived from a report of transdermal delivery of TH in PI by Evans (JPEDS 107:307. 1985). We have shown that transcutaneous sampling of TH ano CF in PI is feasible and speculate that development of this technology may provide a powerful new tool for noninvasively sampling TH or CF therapy in PI.
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Murphy, M., Peck, C., Conner, D. et al. TRANSCUTANEOUS SAMPLING OF THEOPHYLLINE AND CAFFEINE IN PRETERM INFANTS. Pediatr Res 21 (Suppl 4), 239 (1987). https://doi.org/10.1203/00006450-198704010-00433
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DOI: https://doi.org/10.1203/00006450-198704010-00433