Abstract
Low doses of Id may decrease the incidence of intraventricular hemorrhage in prem NB, but its effect on immature cerebral vasoulature and more specifically post endotraoheal suctioning is unknown. Using Doppler technique, 13 prem NB treated with Id for the treatment of patent duotus arteriosus were studied. CBFV of anterior cerebral arteries calculated from the area under the velocity curve (AUTC/min), heart rate (HR), and mean arterial pressure (MABP) were recorded before and 15, 30, 15, 60, and 120 min after the 1st IV injection of Id 0.2 mg/kg (group i, BW: 1269 ± 353 gm, GA: 29 ± .2 wks), and the 3rd injection (group 2, BW: 1490 ± 459 gm, GA: 30 ± 3 wks). Capillary blood gases were obtained before and 60 min after drug injection. MABP, HR, blood gases and pulsatility index were stable throughout the study in both groups. The 1st dose of Id decreased CBFV at 15 min by 22%, and was sustained till 120 min (-28%, p<0.005). CBFV values before 1st and 3rd injection were comparable. CBFV did not change after the 3rd dose. In 5 mechanically ventilated infants, AUTC was also measured pre and post endotracheal suctioning, before and 60 min after each injection. In group 1, the percent increase in CBFV secondary to suctioning was 21.38 ± 27.26 % before Id and 2.77 ± 28.45% 60 min after Id (p<0.02). In contrast, CBFV changes were not significantly affected by the 3rd dose. Thus, an initial dose of Id: 1) decreases resting CBFV, and 2) may attenuate CBFV fluctuations in the prem NB.
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Laudienon, N., Chemtob, S., Bard, H. et al. EFFECT OF INDOMETHACIN (Id) ON THE CEREBRAL BLOOD FLOW VELOCITY (CBFV) OF PREMATURE NEWBORNS (prom NB). Pediatr Res 21 (Suppl 4), 237 (1987). https://doi.org/10.1203/00006450-198704010-00420
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DOI: https://doi.org/10.1203/00006450-198704010-00420