Abstract
The VE response to I.V. bolus infusion of Dox is largely unkown, although Dox is used parenterally in the treatment of apnea of infancy. The objectives of this study were 1) to determine if VE response to Dox changes with postnatal age 2) to characterize the VE response to graded bolus doses of Dox (1 to 10 mg/kg) 3) to partition the peripheral versus the central chemoreceptor response to Dox. Seven intact lambs were studied at 2 and at 15 days of age. Two lambs had carotid body denervation (CBD) at 2 days and were studied at 7 days of age. The animals were studied awake and unsedated. VE was recorded before and continuously for 30 min. after 1 mg/kg Dox I.V. bolus. The study was repeated using 2.5, 5 and 10 mg/kg. The VE response was characterized by a diphasic pattern, an early peak and a late plateau. In the 2 day old VE increases rapidly from 550 to 900 ml/kg/min with 1 mg/ kg, returning to near baseline plateau in 10-12 min. With 2.5 mg/kg, the peak VE was 1000 ml/kg/min. With 5 and 10 mg/kg, the peak VE did not increase further but the plateau VE was shifted to higher VE levels. The same dose response and pattern was seen in the 15 day old lambs. The CBD lambs showed a similar pattern, but the peak response was decreased by more than 50%. Conclusions: 1) no postnatal maturational change was seen in the VE response to Dox 2) Doses >2.5 mg/kg did not increase the peak VE 3) the diminution of the VE by CBD suggests that the peak response is mediated by the peripheral chemoreceptors.
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Blanchard, P., Hobbs, S., Aranda, J. et al. VENTILATORY (VE) RESPONSE TO INTRAVENOUS BOLUS OF DOXAPRAM (DOX) IN NEWBORN LAMBS. Pediatr Res 21 (Suppl 4), 232 (1987). https://doi.org/10.1203/00006450-198704010-00397
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DOI: https://doi.org/10.1203/00006450-198704010-00397