Abstract
To determine the magnitude of steady-state systemic glucose production (GP) used by the brain in 16 fasted 3 hr old term pups, we measured GP with a primed constant infusion of tracer [6-3H] glucose; and cerebral uptake of glucose (CMRG) and O2 (CMRO2) taken as the product of arteriovenous difference of substrate and cerebral blood flow (CBF), as measured by the FICK principle with 14C-antipyrine. The following static parameters were:
Oxygen/glucose index was 52.9±9.17%. Glucose extracted by the brain (A-V/A) was 27.6±4.1%. 36.6% of systemic GP was accounted for by brain uptake. The brain utilized 11.42±1.6 μm/kg/min of glucose provided by GP. Within the range of glucose levels, glucose did not correlate with CBF, CMRG or CMRO2. CMRG was not related to GP. In contrast A-V/A decreased as an exponential function of glucose (r=-0.51, p<0.05). Furthermore, percent of GP used by the brain was an inverse function of GP (r=-0.71, p<0.001). IN CONCLUSION: although the brain is 2.3% of body wt, it uses 36% of GP. Secondly, within this range of glucose, CMRG is not affected and may be maintained by increased extraction at the lower end of blood glucose spectrum.
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Huang, M., Kliegman, R., Voelker, K. et al. RELATIONSHIP OF SYSTEMIC GLUCOSE PRODUCTION TO CEREBRAL GLUCOSE UTILIZATION IN NEWBORN DOGS. Pediatr Res 21 (Suppl 4), 215 (1987). https://doi.org/10.1203/00006450-198704010-00296
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DOI: https://doi.org/10.1203/00006450-198704010-00296